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AAAI
1998
15 years 8 months ago
Automated Intelligent Pilots for Combat Flight Simulation
TacAir-Soar is an intelligent, rule-based system that generates believable human-like" behavior for military simulations. The innovation of the application is primarily a mat...
Randolph M. Jones, John E. Laird, Paul E. Nielsen
BMCBI
2008
102views more  BMCBI 2008»
15 years 7 months ago
Stability of the core domain of p53: insights from computer simulations
: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p...
Arumugam Madhumalar, Derek John Smith, Chandra Ver...
BMCBI
2008
77views more  BMCBI 2008»
15 years 7 months ago
Stochastic models for the in silico simulation of synaptic processes
Background: Research in life sciences is benefiting from a large availability of formal description techniques and analysis methodologies. These allow both the phenomena investiga...
Andrea Bracciali, Marcello Brunelli, Enrico Catald...
CORR
2010
Springer
111views Education» more  CORR 2010»
15 years 7 months ago
Submodular Maximization by Simulated Annealing
We consider the problem of maximizing a nonnegative (possibly non-monotone) submodular set function with or without constraints. Feige et al. [9] showed a 2/5-approximation for th...
Shayan Oveis Gharan, Jan Vondrák
BMCBI
2006
85views more  BMCBI 2006»
15 years 7 months ago
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
Rui Jiang, Hua Yang, Fengzhu Sun, Ting Chen