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BMCBI
2006
119views more  BMCBI 2006»
14 years 11 months ago
A methodology for the structural and functional analysis of signaling and regulatory networks
Background: Structural analysis of cellular interaction networks contributes to a deeper understanding of network-wide interdependencies, causal relationships, and basic functiona...
Steffen Klamt, Julio Saez-Rodriguez, Jonathan A. L...
BMCBI
2006
85views more  BMCBI 2006»
14 years 11 months ago
Quality control for terms and definitions in ontologies and taxonomies
Background: Ontologies and taxonomies are among the most important computational resources for molecular biology and bioinformatics. A series of recent papers has shown that the G...
Jacob Köhler, Katherine Munn, Alexander R&uum...
BMCBI
2006
103views more  BMCBI 2006»
14 years 11 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
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BMCBI
2006
88views more  BMCBI 2006»
14 years 11 months ago
Effect of various normalization methods on Applied Biosystems expression array system data
Background: DNA microarray technology provides a powerful tool for characterizing gene expression on a genome scale. While the technology has been widely used in discovery-based m...
Catalin C. Barbacioru, Yulei Wang, Roger D. Canale...
COMPUTER
2006
84views more  COMPUTER 2006»
14 years 11 months ago
Testable, Reusable Units of Cognition
The educational content of a technical topic consists, ultimately, of elementary chunks of knowledge. Identifying and classifying such units -- Testable, Reusable Units of Cogniti...
Bertrand Meyer