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BMCBI
2005
122views more  BMCBI 2005»
15 years 1 months ago
Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
Jiajian Liu, Gary D. Stormo
BMCBI
2005
116views more  BMCBI 2005»
15 years 1 months ago
Which gene did you mean?
Computational Biology needs computer-readable information records. Increasingly, meta-analysed and pre-digested information is being used in the follow up of high throughput exper...
Barend Mons
BMCBI
2005
147views more  BMCBI 2005»
15 years 1 months ago
GATA: a graphic alignment tool for comparative sequence analysis
Background: Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved se...
David A. Nix, Michael B. Eisen
BMCBI
2005
87views more  BMCBI 2005»
15 years 1 months ago
ProfNet, a method to derive profile-profile alignment scoring functions that improves the alignments of distantly related protei
Background: Profile-profile methods have been used for some years now to detect and align homologous proteins. The best such methods use information from the background distributi...
Tomas Ohlson, Arne Elofsson
BMCBI
2005
115views more  BMCBI 2005»
15 years 1 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
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