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BMCBI
2010
133views more  BMCBI 2010»
14 years 10 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2007
135views more  BMCBI 2007»
14 years 10 months ago
LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise
Background: Mass spectrometry protein profiling is a promising tool for biomarker discovery in clinical proteomics. However, the development of a reliable approach for the separat...
Dante Mantini, Francesca Petrucci, Damiana Pierago...
BMCBI
2007
125views more  BMCBI 2007»
14 years 10 months ago
Bayesian meta-analysis models for microarray data: a comparative study
Background: With the growing abundance of microarray data, statistical methods are increasingly needed to integrate results across studies. Two common approaches for meta-analysis...
Erin M. Conlon, Joon J. Song, Anna Liu
BMCBI
2007
114views more  BMCBI 2007»
14 years 10 months ago
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
Allegra Via, Pier Federico Gherardini, Enrico Ferr...
BMCBI
2007
152views more  BMCBI 2007»
14 years 10 months ago
Difference-based clustering of short time-course microarray data with replicates
Background: There are some limitations associated with conventional clustering methods for short time-course gene expression data. The current algorithms require prior domain know...
Jihoon Kim, Ju Han Kim