Sequence comparison is considered as a cornerstone application in bioinformatics, which forms the basis of many other applications. In particular, pairwise sequence alignment is a...
Ankit Agrawal, Sanchit Misra, Daniel Honbo, Alok N...
Background: It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding si...
Dustin E. Schones, Andrew D. Smith, Michael Q. Zha...
Background: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistical...
Background: Serial analysis of gene expression (SAGE) is used to obtain quantitative snapshots of the transcriptome. These profiles are count-based and are assumed to follow a Bin...
We address the issue of judging the significance of rare events as it typically arises in statistical naturallanguage processing. We first define a general approach to the problem...