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BMCBI
2006
159views more  BMCBI 2006»
14 years 9 months ago
EpiJen: a server for multistep T cell epitope prediction
Background: The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated...
Irini A. Doytchinova, Pingping Guan, Darren R. Flo...
BMCBI
2006
93views more  BMCBI 2006»
14 years 9 months ago
Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR
Background: In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all re...
Rasmus Goll, Trine Olsen, Guanglin Cui, Jon Florho...
BMCBI
2006
152views more  BMCBI 2006»
14 years 9 months ago
Amplification of the Gene Ontology annotation of Affymetrix probe sets
Background: The annotations of Affymetrix DNA microarray probe sets with Gene Ontology terms are carefully selected for correctness. This results in very accurate but incomplete a...
Enrique M. Muro, Carolina Perez-Iratxeta, Miguel A...
BMCBI
2006
92views more  BMCBI 2006»
14 years 9 months ago
Similarity-based gene detection: using COGs to find evolutionarily-conserved ORFs
Background: Experimental verification of gene products has not kept pace with the rapid growth of microbial sequence information. However, existing annotations of gene locations c...
Bradford C. Powell, Clyde A. Hutchison III
BMCBI
2006
107views more  BMCBI 2006»
14 years 9 months ago
Analysis of optimal phenotypic space using elementary modes as applied to Corynebacterium glutamicum
Background: Quantification of the metabolic network of an organism offers insights into possible ways of developing mutant strain for better productivity of an extracellular metab...
Kalyan Gayen, K. V. Venkatesh