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BMCBI
2010
121views more  BMCBI 2010»
14 years 10 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
BMCBI
2007
227views more  BMCBI 2007»
14 years 10 months ago
Growing functional modules from a seed protein via integration of protein interaction and gene expression data
Background: Nowadays modern biology aims at unravelling the strands of complex biological structures such as the protein-protein interaction (PPI) networks. A key concept in the o...
Ioannis A. Maraziotis, Konstantina Dimitrakopoulou...
BMCBI
2007
89views more  BMCBI 2007»
14 years 10 months ago
Comparing segmentations by applying randomization techniques
Background: There exist many segmentation techniques for genomic sequences, and the segmentations can also be based on many different biological features. We show how to evaluate ...
Niina Haiminen, Heikki Mannila, Evimaria Terzi
BMCBI
2008
144views more  BMCBI 2008»
14 years 10 months ago
PDTD: a web-accessible protein database for drug target identification
Background: Target identification is important for modern drug discovery. With the advances in the development of molecular docking, potential binding proteins may be discovered b...
Zhenting Gao, Honglin Li, Hailei Zhang, Xiaofeng L...
BMCBI
2008
153views more  BMCBI 2008»
14 years 10 months ago
Improved general regression network for protein domain boundary prediction
Background: Protein domains present some of the most useful information that can be used to understand protein structure and functions. Recent research on protein domain boundary ...
Paul D. Yoo, Abdur R. Sikder, Bing Bing Zhou, Albe...