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129
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BMCBI
2010
15 years 16 days ago
2010
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
131
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BMCBI
2006
15 years 14 days ago
2006
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
105
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CIBCB
2006
IEEE
15 years 6 months ago
2006
IEEE
Abstract— Quantum mechanics and molecular dynamic simulation provide important insights into structural configurations and molecular interaction data today. To extend this atomi...
119
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BMCBI
2007
15 years 16 days ago
2007
Background: Current approaches to parameter estimation are often inappropriate or inconvenient for the modelling of complex biological systems. For systems described by nonlinear ...
109
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TCS
2011
14 years 7 months ago
2011
Boolean networks have long been used as models of molecular networks and play an increasingly important role in systems biology. This paper describes a software package, offered ...