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BMCBI
2010
116views more  BMCBI 2010»
14 years 10 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BIOINFORMATICS
2006
134views more  BIOINFORMATICS 2006»
14 years 10 months ago
HaptenDB: a comprehensive database of haptens, carrier proteins and anti-hapten antibodies
The key requirement for successful immunochemical assay is the availability of antibodies with high specificity and desired affinity. Small molecules, when used as haptens, are no...
Mahender Kumar Singh, Shilpy Srivastava, G. P. S. ...
CORR
2010
Springer
189views Education» more  CORR 2010»
14 years 9 months ago
An Optimal Dynamic Mechanism for Multi-Armed Bandit Processes
We consider the problem of revenue-optimal dynamic mechanism design in settings where agents' types evolve over time as a function of their (both public and private) experien...
Sham M. Kakade, Ilan Lobel, Hamid Nazerzadeh
CVPR
2008
IEEE
16 years 12 hour ago
Learning stick-figure models using nonparametric Bayesian priors over trees
We present a fully probabilistic stick-figure model that uses a nonparametric Bayesian distribution over trees for its structure prior. Sticks are represented by nodes in a tree i...
Edward Meeds, David A. Ross, Richard S. Zemel, Sam...
ICML
2009
IEEE
15 years 10 months ago
A Bayesian approach to protein model quality assessment
Given multiple possible models b1, b2, . . . bn for a protein structure, a common sub-task in in-silico Protein Structure Prediction is ranking these models according to their qua...
Hetunandan Kamisetty, Christopher James Langmead