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BMCBI
2010
133views more  BMCBI 2010»
15 years 5 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
IMSCCS
2007
IEEE
15 years 11 months ago
Asymmetric Bagging and Feature Selection for Activities Prediction of Drug Molecules
Background: Activities of drug molecules can be predicted by QSAR (quantitative structure activity relationship) models, which overcomes the disadvantages of high cost and long cy...
Guo-Zheng Li, Hao-Hua Meng, Mary Qu Yang, Jack Y. ...
BMCBI
2010
190views more  BMCBI 2010»
15 years 5 months ago
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
Background: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understandin...
Jun-Feng Xia, Xing-Ming Zhao, Jiangning Song, De-S...
BMCBI
2008
134views more  BMCBI 2008»
15 years 5 months ago
Prediction of protein-protein binding site by using core interface residue and support vector machine
Background: The prediction of protein-protein binding site can provide structural annotation to the protein interaction data from proteomics studies. This is very important for th...
Nan Li, Zhonghua Sun, Fan Jiang
SIGSOFT
2008
ACM
16 years 5 months ago
Predicting failures with developer networks and social network analysis
Software fails and fixing it is expensive. Research in failure prediction has been highly successful at modeling software failures. Few models, however, consider the key cause of ...
Andrew Meneely, Laurie Williams, Will Snipes, Jaso...