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BMCBI
2007
128views more  BMCBI 2007»
15 years 1 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
ICEIS
2003
IEEE
15 years 7 months ago
The Protein Structure Prediction Module of the Prot-Grid Information System
: In this work, we describe the protein secondary structure prediction module of a distributed bio-informatics system. Protein databases contain over a million of sequenced protein...
Dimitrios Vogiatzis, Dimitrios Frosyniotis, George...
ISMB
1996
15 years 3 months ago
A Knowledge-Based Method for Protein Structure Refinement and Prediction
The native conformation of a protein, in a given environment, is determined entirely by the various interatomic interactions dictated by the amino acid sequence (1-3). We describe...
Shankar Subramaniam, David K. Tcheng, James M. Fen...
BMCBI
2008
138views more  BMCBI 2008»
15 years 2 months ago
Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represent...
Ching-Wai Tan, David T. Jones
BIBE
2007
IEEE
138views Bioinformatics» more  BIBE 2007»
15 years 8 months ago
A Flexible Stem-Based Local Search Algorithm for Predicting RNA Secondary Structures Including Pseudoknots
-We demonstrate a new algorithm named FlexStem to predict RNA secondary structures with pseudoknots. Our approach is based on the free energy minimization criterion, and utilizes a...
Xiang Chen, Simin He, Dongbo Bu, Runsheng Chen, We...