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BMCBI
2008
98views more  BMCBI 2008»
14 years 10 months ago
GBNet: Deciphering regulatory rules in the co-regulated genes using a Gibbs sampler enhanced Bayesian network approach
Background: Combinatorial regulation of transcription factors (TFs) is important in determining the complex gene expression patterns particularly in higher organisms. Deciphering ...
Li Shen, Jie Liu, Wei Wang
BMCBI
2008
83views more  BMCBI 2008»
14 years 10 months ago
Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
Background: Microarray technology has unveiled transcriptomic differences among tumors of various phenotypes, and, especially, brought great progress in molecular understanding of...
Atsushi Niida, Andrew D. Smith, Seiya Imoto, Shuic...
COCOON
2008
Springer
14 years 11 months ago
Quasi-bicliques: Complexity and Binding Pairs
Abstract. Protein-protein interactions (PPIs) are one of the most important mechanisms in cellular processes. To model protein interaction sites, recent studies have suggested to f...
Xiaowen Liu, Jinyan Li, Lusheng Wang
NAR
1998
101views more  NAR 1998»
14 years 9 months ago
The PRINTS protein fingerprint database in its fifth year
PRINTS is a database of protein family ‘fingerprints’ offering a diagnostic resource for newly-determined sequences. By contrast with PROSITE, which uses single consensus expr...
Terri K. Attwood, Michael E. Beck, Darren R. Flowe...
GCB
2009
Springer
105views Biometrics» more  GCB 2009»
15 years 4 months ago
Maximum Likelihood Estimation of Weight Matrices for Targeted Homology Search
: Genome annotation relies to a large extent on the recognition of homologs to already known genes. The starting point for such protocols is a collection of known sequences from on...
Peter Menzel, Jan Gorodkin, Peter F. Stadler