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BMCBI
2004
148views more  BMCBI 2004»
14 years 9 months ago
Bioinformatics analysis of SARS coronavirus genome polymorphism
Background: We have compared 38 isolates of the SARS-CoV complete genome. The main goal was twofold: first, to analyze and compare nucleotide sequences and to identify positions o...
Gordana Pavlovic-Lazetic, Nenad S. Mitic, Milos V....
BMCBI
2004
120views more  BMCBI 2004»
14 years 9 months ago
Optimal cDNA microarray design using expressed sequence tags for organisms with limited genomic information
Background: Expression microarrays are increasingly used to characterize environmental responses and hostparasite interactions for many different organisms. Probe selection for cD...
Yian A. Chen, David J. Mckillen, Shuyuan Wu, Matth...
BMCBI
2004
96views more  BMCBI 2004»
14 years 9 months ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
BMCBI
2004
96views more  BMCBI 2004»
14 years 9 months ago
A hybrid clustering approach to recognition of protein families in 114 microbial genomes
Background: Grouping proteins into sequence-based clusters is a fundamental step in many bioinformatic analyses (e.g., homology-based prediction of structure or function). Standar...
Timothy J. Harlow, J. Peter Gogarten, Mark A. Raga...
BIOINFORMATICS
2004
90views more  BIOINFORMATICS 2004»
14 years 9 months ago
GDPC: connecting researchers with multiple integrated data sources
Summary: The goal of this project is to simplify access to genomic diversity and phenotype data, thereby encouraging reuse of this data. The Genomic Diversity and Phenotype Connec...
Terry M. Casstevens, Edward S. Buckler