Recent studies suggest that the mammalian genomes can be subdivided in segments within which there is limited haplotype diversity. Understanding the distribution and structure of ...
Jeremy W. Wang, Kyle J. Moore, Qi Zhang, Fernando ...
Background: Over the last few years, genome-wide association (GWA) studies became a tool of choice for the identification of loci associated with complex traits. Currently, impute...
Yurii S. Aulchenko, Maksim V. Struchalin, Cornelia...
Background: Genotype information generated by individual and international efforts carries the promise of revolutionizing disease studies and the association of phenotypes with al...
A major challenge for genomewide disease association studies is the high cost of genotyping large number of single nucleotide polymorphisms (SNP). The correlations between SNPs, h...
Background: Forward-time simulations have unique advantages in power and flexibility for the simulation of genetic samples of complex human diseases because they can closely mimic...