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» Target SNP selection in complex disease association studies
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BMCBI
2011
14 years 1 months ago
Robust joint analysis allowing for model uncertainty in two-stage genetic association studies
Background: The cost efficient two-stage design is often used in genome-wide association studies (GWASs) in searching for genetic loci underlying the susceptibility for complex di...
Dongdong Pan, Qizhai Li, Ningning Jiang, Aiyi Liu,...
JMLR
2010
97views more  JMLR 2010»
14 years 4 months ago
Evaluation of a Bayesian model-based approach in GA studies
In a typical Genetic Association Study (GAS) several hundreds to millions of genomic variables are measured and tested for association with a given set of a phenotypic variables (...
Gábor Hullám, Peter Antal, Csaba Sza...
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BMCBI
2006
169views more  BMCBI 2006»
14 years 9 months ago
Comparative analysis of haplotype association mapping algorithms
Background: Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative trail loci (QTL) in miceuse an F2 cross b...
Phillip McClurg, Mathew T. Pletcher, Tim Wiltshire...
BMCBI
2010
114views more  BMCBI 2010»
14 years 9 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
BIBE
2004
IEEE
15 years 1 months ago
Identifying the Combination of Genetic Factors that Determine Susceptibility to Cervical Cancer
Cervical cancer is common among women all over the world. Although infection with high-risk types of human papillomavirus (HPV) has been identified as the primary cause of cervical...
Jorng-Tzong Horng, Kai-Chih Hu, Li-Cheng Wu, Hsien...