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149
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BMCBI
2007
15 years 4 months ago
2007
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
143
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BMCBI
2008
15 years 4 months ago
2008
Background: The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false po...
111
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BMCBI
2008
15 years 4 months ago
2008
Background: Modelling proteins with multiple domains is one of the central challenges in Structural Biology. Although homology modelling has successfully been applied for predicti...
121
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BMCBI
2008
15 years 4 months ago
2008
Background: Protein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentallym...
148
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BMCBI
2008
15 years 4 months ago
2008
Background: The prediction of protein structure can be facilitated by the use of constraints based on a knowledge of functional sites. Without this information it is still possibl...