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CEC
2010
IEEE
15 years 1 months ago
Learning-assisted evolutionary search for scalable function optimization: LEM(ID3)
Inspired originally by the Learnable Evolution Model(LEM) [5], we investigate LEM(ID3), a hybrid of evolutionary search with ID3 decision tree learning. LEM(ID3) involves interleav...
Guleng Sheri, David Corne
123
Voted
BMCBI
2010
113views more  BMCBI 2010»
15 years 28 days ago
A classification model for distinguishing copy number variants from cancer-related alterations
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
Irina Ostrovnaya, Gouri Nanjangud, Adam B. Olshen
101
Voted
BMCBI
2010
108views more  BMCBI 2010»
15 years 28 days ago
Confronting two-pair primer design for enzyme-free SNP genotyping based on a genetic algorithm
Background: Polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method produces allelespecific DNA bands of different lengths by adding four designed primers an...
Cheng-Hong Yang, Yu-Huei Cheng, Li-Yeh Chuang, Hsu...
BMCBI
2008
142views more  BMCBI 2008»
15 years 28 days ago
Strategies for measuring evolutionary conservation of RNA secondary structures
Background: Evolutionary conservation of RNA secondary structure is a typical feature of many functional non-coding RNAs. Since almost all of the available methods used for predic...
Andreas R. Gruber, Stephan H. F. Bernhart, Ivo L. ...
100
Voted
BMCBI
2008
107views more  BMCBI 2008»
15 years 28 days ago
Probe-specific mixed-model approach to detect copy number differences using multiplex ligation-dependent probe amplification (ML
Background: MLPA method is a potentially useful semi-quantitative method to detect copy number alterations in targeted regions. In this paper, we propose a method for the normaliz...
Juan R. González, Josep L. Carrasco, Llu&ia...