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BMCBI
2010
158views more  BMCBI 2010»
15 years 21 days ago
Validation of differential gene expression algorithms: Application comparing fold-change estimation to hypothesis testing
Background: Sustained research on the problem of determining which genes are differentially expressed on the basis of microarray data has yielded a plethora of statistical algorit...
Corey M. Yanofsky, David R. Bickel
131
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BMCBI
2006
147views more  BMCBI 2006»
15 years 19 days ago
Grouping Gene Ontology terms to improve the assessment of gene set enrichment in microarray data
Background: Gene Ontology (GO) terms are often used to assess the results of microarray experiments. The most common way to do this is to perform Fisher's exact tests to find...
Alex Lewin, Ian C. Grieve
BMCBI
2008
128views more  BMCBI 2008»
15 years 21 days ago
Validation of an NSP-based (negative selection pattern) gene family identification strategy
Background: Gene family identification from ESTs can be a valuable resource for analysis of genome evolution but presents unique challenges in organisms for which the entire genom...
Ronald L. Frank, Cyriac Kandoth, Fikret Erç...
76
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ISMB
1996
15 years 1 months ago
Gene Prediction by Pattern Recognition and Homology Search
This paper presents an algorithm for combining pattern recognition-based exon prediction and database homologysearch in gene model construction. Thegoal is to use homologousgeneso...
Ying Xu, Edward C. Uberbacher
BMCBI
2007
140views more  BMCBI 2007»
15 years 18 days ago
Evaluation of high-throughput functional categorization of human disease genes
Background: Biological data that are well-organized by an ontology, such as Gene Ontology, enables high-throughput availability of the semantic web. It can also be used to facilit...
James L. Chen, Yang Liu, Lee T. Sam, Jianrong Li, ...