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BMCBI
2010
96views more  BMCBI 2010»
15 years 23 days ago
QTLminer: identifying genes regulating quantitative traits
Background: Quantitative trait locus (QTL) mapping identifies genomic regions that likely contain genes regulating a quantitative trait. However, QTL regions may encompass tens to...
Rudi Alberts, Klaus Schughart
104
Voted
BMCBI
2007
138views more  BMCBI 2007»
15 years 23 days ago
A full Bayesian hierarchical mixture model for the variance of gene differential expression
Background: In many laboratory-based high throughput microarray experiments, there are very few replicates of gene expression levels. Thus, estimates of gene variances are inaccur...
Samuel O. M. Manda, Rebecca E. Walls, Mark S. Gilt...
107
Voted
BMCBI
2006
129views more  BMCBI 2006»
15 years 21 days ago
Identifying genes that contribute most to good classification in microarrays
Background: The goal of most microarray studies is either the identification of genes that are most differentially expressed or the creation of a good classification rule. The dis...
Stuart G. Baker, Barnett S. Kramer
87
Voted
BIBE
2007
IEEE
176views Bioinformatics» more  BIBE 2007»
15 years 7 months ago
HICCUP: Hierarchical Clustering Based Value Imputation using Heterogeneous Gene Expression Microarray Datasets
Abstract—A novel microarray value imputation method, HICCUP1 , is presented. HICCUP improves upon existing value imputation methods in the several ways. (1) By judiciously integr...
Qiankun Zhao, Prasenjit Mitra, Dongwon Lee, Jaewoo...
BMCBI
2008
142views more  BMCBI 2008»
15 years 23 days ago
Microarray data mining: A novel optimization-based approach to uncover biologically coherent structures
Background: DNA microarray technology allows for the measurement of genome-wide expression patterns. Within the resultant mass of data lies the problem of analyzing and presenting...
Meng Piao Tan, Erin N. Smith, James R. Broach, Chr...