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» The Case for Grounding Databases
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BMCBI
2006
138views more  BMCBI 2006»
15 years 1 months ago
Determination of strongly overlapping signaling activity from microarray data
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
Ghislain Bidaut, Karsten Suhre, Jean-Michel Claver...
BMCBI
2006
152views more  BMCBI 2006»
15 years 1 months ago
Amplification of the Gene Ontology annotation of Affymetrix probe sets
Background: The annotations of Affymetrix DNA microarray probe sets with Gene Ontology terms are carefully selected for correctness. This results in very accurate but incomplete a...
Enrique M. Muro, Carolina Perez-Iratxeta, Miguel A...
BMCBI
2007
194views more  BMCBI 2007»
15 years 1 months ago
A meta-data based method for DNA microarray imputation
Background: DNA microarray experiments are conducted in logical sets, such as time course profiling after a treatment is applied to the samples, or comparisons of the samples unde...
Rebecka Jörnsten, Ming Ouyang, Hui-Yu Wang
BMCBI
2007
120views more  BMCBI 2007»
15 years 1 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
BMCBI
2007
107views more  BMCBI 2007»
15 years 1 months ago
Linking microarray reporters with protein functions
Background: The analysis of microarray experiments requires accurate and up-to-date functional annotation of the microarray reporters to optimize the interpretation of the biologi...
Stan Gaj, Arie van Erk, Rachel I. M. van Haaften, ...