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» The Complexity of Global Constraints
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105
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BMCBI
2007
143views more  BMCBI 2007»
15 years 19 days ago
An adaptive bin framework search method for a beta-sheet protein homopolymer model
Background: The problem of protein structure prediction consists of predicting the functional or native structure of a protein given its linear sequence of amino acids. This probl...
Alena Shmygelska, Holger H. Hoos
109
Voted
BMCBI
2008
104views more  BMCBI 2008»
15 years 19 days ago
ReRep: Computational detection of repetitive sequences in genome survey sequences (GSS)
Background: Genome survey sequences (GSS) offer a preliminary global view of a genome since, unlike ESTs, they cover coding as well as non-coding DNA and include repetitive region...
Thomas D. Otto, Leonardo H. F. Gomes, Marcelo Alve...
124
Voted
BMCBI
2008
104views more  BMCBI 2008»
15 years 19 days ago
Comparison of methods for estimating the nucleotide substitution matrix
Background: The nucleotide substitution rate matrix is a key parameter of molecular evolution. Several methods for inferring this parameter have been proposed, with different math...
Maribeth Oscamou, Daniel McDonald, Von Bing Yap, G...
102
Voted
BMCBI
2008
211views more  BMCBI 2008»
15 years 19 days ago
CPSP-tools - Exact and complete algorithms for high-throughput 3D lattice protein studies
Background: The principles of protein folding and evolution pose problems of very high inherent complexity. Often these problems are tackled using simplified protein models, e.g. ...
Martin Mann, Sebastian Will, Rolf Backofen
BMCBI
2008
102views more  BMCBI 2008»
15 years 19 days ago
Improving protein function prediction methods with integrated literature data
Background: Determining the function of uncharacterized proteins is a major challenge in the post-genomic era due to the problem's complexity and scale. Identifying a protein...
Aaron Gabow, Sonia M. Leach, William A. Baumgartne...