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BIOINFORMATICS
2012
12 years 12 months ago
Epigenetic priors for identifying active transcription factor binding sites
Motivation Accurate knowledge of the genome-wide binding of transcription factors in a particular cell type or under a particular condition is necessary for understanding transcri...
Gabriel Cuellar-Partida, Fabian A. Buske, Robert C...
STOC
2009
ACM
271views Algorithms» more  STOC 2009»
15 years 10 months ago
A fast and efficient algorithm for low-rank approximation of a matrix
The low-rank matrix approximation problem involves finding of a rank k version of a m ? n matrix AAA, labeled AAAk, such that AAAk is as "close" as possible to the best ...
Nam H. Nguyen, Thong T. Do, Trac D. Tran
DAC
1999
ACM
15 years 1 months ago
Panel: What is the Proper System on Chip Design Methodology
ion model or flexible PCB solutions cannot offer a valid solution for the next millinium SoCs . James G. Dougherty, Integrated Systems Silicon LTD, Belfast, Northern Ireland ISS an...
Richard Goering, Pierre Bricaud, James G. Doughert...
BMCBI
2010
119views more  BMCBI 2010»
14 years 9 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
BMCBI
2010
167views more  BMCBI 2010»
14 years 9 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...