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» The Expression Problem Revisited
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BMCBI
2010
99views more  BMCBI 2010»
15 years 4 months ago
Different effects of the probe summarization algorithms PLIER and RMA on high-level analysis of Affymetrix exon arrays
Background: Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized pla...
Yi Qu, Fei He, Yuchen Chen
BMCBI
2010
115views more  BMCBI 2010»
15 years 4 months ago
Assessment and optimisation of normalisation methods for dual-colour antibody microarrays
Background: Recent advances in antibody microarray technology have made it possible to measure the expression of hundreds of proteins simultaneously in a competitive dual-colour a...
Martin Sill, Christoph Schroder, Jörg D. Hohe...
BMCBI
2006
95views more  BMCBI 2006»
15 years 4 months ago
XcisClique: analysis of regulatory bicliques
Background: Modeling of cis-elements or regulatory motifs in promoter (upstream) regions of genes is a challenging computational problem. In this work, set of regulatory motifs si...
Amrita Pati, Cecilia Vasquez-Robinet, Lenwood S. H...
BMCBI
2008
146views more  BMCBI 2008»
15 years 4 months ago
Rank-based edge reconstruction for scale-free genetic regulatory networks
Background: The reconstruction of genetic regulatory networks from microarray gene expression data has been a challenging task in bioinformatics. Various approaches to this proble...
Guanrao Chen, Peter Larsen, Eyad Almasri, Yang Dai
ACML
2009
Springer
15 years 10 months ago
Automatic Choice of Control Measurements
Abstract. In experimental design, a standard approach for distinguishing experimentally induced effects from unwanted effects is to design control measurements that differ only ...
Gayle Leen, David R. Hardoon, Samuel Kaski