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BMCBI
2010
100views more  BMCBI 2010»
14 years 8 months ago
New insights into protein-protein interaction data lead to increased estimates of the S. cerevisiae interactome size
Background: As protein interactions mediate most cellular mechanisms, protein-protein interaction networks are essential in the study of cellular processes. Consequently, several ...
Laure Sambourg, Nicolas Thierry-Mieg
BMCBI
2010
142views more  BMCBI 2010»
14 years 8 months ago
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
Background: High-throughput profiling of DNA methylation status of CpG islands is crucial to understand the epigenetic regulation of genes. The microarray-based Infinium methylati...
Pan Du, Xiao Zhang, Chiang-Ching Huang, Nadereh Ja...
BMCBI
2010
121views more  BMCBI 2010»
14 years 8 months ago
Computing DNA duplex instability profiles efficiently with a two-state model: trends of promoters and binding sites
Background: DNA instability profiles have been used recently for predicting the transcriptional start site and the location of core promoters, and to gain insight into promoter ac...
Miriam R. Kantorovitz, Zoi Rapti, Vladimir Gelev, ...
BMCBI
2010
143views more  BMCBI 2010»
14 years 8 months ago
A genome alignment algorithm based on compression
Background: Traditional genome alignment methods consider sequence alignment as a variation of the string edit distance problem, and perform alignment by matching characters of th...
Minh Duc Cao, Trevor I. Dix, Lloyd Allison
BMCBI
2010
218views more  BMCBI 2010»
14 years 8 months ago
A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D
Background: To exploit the flood of data from advances in high throughput imaging of optically sectioned nuclei, image analysis methods need to correctly detect thousands of nucle...
Anthony Santella, Zhuo Du, Sonja Nowotschin, Anna-...
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