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» The LIFEdb database in 2006
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BIOINFORMATICS
2006
129views more  BIOINFORMATICS 2006»
15 years 1 months ago
Predicting methylation status of CpG islands in the human brain
Motivation: Over 50% of human genes contain CpG islands in their 5'-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulatio...
Fang Fang, Shicai Fan, Xuegong Zhang, Michael Q. Z...
BMCBI
2006
137views more  BMCBI 2006»
15 years 1 months ago
Improving the accuracy of protein secondary structure prediction using structural alignment
Background: The accuracy of protein secondary structure prediction has steadily improved over the past 30 years. Now many secondary structure prediction methods routinely achieve ...
Scott Montgomerie, Shan Sundararaj, Warren J. Gall...
BMCBI
2006
84views more  BMCBI 2006»
15 years 1 months ago
Representation of target-bound drugs by computed conformers: implications for conformational libraries
Background: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead com...
Stefan Günther, Christian Senger, Elke Michal...
BMCBI
2006
124views more  BMCBI 2006»
15 years 1 months ago
Predicting transcription factor binding sites using local over-representation and comparative genomics
Background: Identifying cis-regulatory elements is crucial to understanding gene expression, which highlights the importance of the computational detection of overrepresented tran...
Matthieu Defrance, Hélène Touzet
CANDC
2006
ACM
15 years 1 months ago
Domain boundary prediction based on profile domain linker propensity index
Successful prediction of protein domain boundaries provides valuable information not only for the computational structure prediction of multidomain proteins but also for the exper...
Qiwen Dong, Xiaolong Wang, Lei Lin, Zhiming Xu