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98
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BMCBI
2007
168views more  BMCBI 2007»
14 years 11 months ago
GOSim - an R-package for computation of information theoretic GO similarities between terms and gene products
Background: With the increased availability of high throughput data, such as DNA microarray data, researchers are capable of producing large amounts of biological data. During the...
Holger Fröhlich, Nora Speer, Annemarie Poustk...
86
Voted
BMCBI
2008
120views more  BMCBI 2008»
14 years 11 months ago
A protein interaction based model for schizophrenia study
Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susc...
Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih...
88
Voted
AIM
2006
14 years 11 months ago
Comparative Analysis of Frameworks for Knowledge-Intensive Intelligent Agents
maintain awareness of its environment for a long period of time. Additionally, knowledge-intensive agents must be engineered such that their knowledge can be easily updated as envi...
Randolph M. Jones, Robert E. Wray III
71
Voted
BMCBI
2006
86views more  BMCBI 2006»
14 years 11 months ago
The impact of sample imbalance on identifying differentially expressed genes
Background: Recently several statistical methods have been proposed to identify genes with differential expression between two conditions. However, very few studies consider the p...
Kun Yang, Jianzhong Li, Hong Gao
BMCBI
2006
101views more  BMCBI 2006»
14 years 11 months ago
Hierarchical modularity of nested bow-ties in metabolic networks
Background: The exploration of the structural topology and the organizing principles of genomebased large-scale metabolic networks is essential for studying possible relations bet...
Jing Zhao, Hong Yu, Jianhua Luo, Zhi-Wei Cao, Yi-X...