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96
Voted
BMCBI
2006
159views more  BMCBI 2006»
15 years 22 days ago
Prediction of protein continuum secondary structure with probabilistic models based on NMR solved structures
Background: The structure of proteins may change as a result of the inherent flexibility of some protein regions. We develop and explore probabilistic machine learning methods for...
Mikael Bodén, Zheng Yuan, Timothy L. Bailey
BMCBI
2008
93views more  BMCBI 2008»
15 years 24 days ago
A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate
Background: A JavaTM application is presented, which compares large numbers (n > 100) of raw FTICR mass spectra from patients and controls. Two peptide profile matrices can be ...
Mark K. Titulaer, Dana A. N. Mustafa, Ivar Siccama...
99
Voted
BMCBI
2008
142views more  BMCBI 2008»
15 years 23 days ago
Optimal neighborhood indexing for protein similarity search
Background: Similarity inference, one of the main bioinformatics tasks, has to face an exponential growth of the biological data. A classical approach used to cope with this data ...
Pierre Peterlongo, Laurent Noé, Dominique L...
112
Voted
NAR
2008
107views more  NAR 2008»
15 years 19 days ago
ISPIDER Central: an integrated database web-server for proteomics
Despite the growing volumes of proteomic data, integration of the underlying results remains problematic owing to differences in formats, data captured, protein accessions and ser...
Jennifer A. Siepen, Khalid Belhajjame, Julian N. S...
96
Voted
ICML
2009
IEEE
16 years 1 months ago
A Bayesian approach to protein model quality assessment
Given multiple possible models b1, b2, . . . bn for a protein structure, a common sub-task in in-silico Protein Structure Prediction is ranking these models according to their qua...
Hetunandan Kamisetty, Christopher James Langmead