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JDA
2011
104views more  JDA 2011»
14 years 5 months ago
Deconstructing intractability - A multivariate complexity analysis of interval constrained coloring
The NP-hard Interval Constrained Coloring (ICC) problem appears in the interpretation of experimental data in biochemistry dealing with protein fragments. Given a set of m integer...
Christian Komusiewicz, Rolf Niedermeier, Johannes ...
BMCBI
2010
151views more  BMCBI 2010»
14 years 10 months ago
Classification of G-protein coupled receptors based on support vector machine with maximum relevance minimum redundancy and gene
Background: Because a priori knowledge about function of G protein-coupled receptors (GPCRs) can provide useful information to pharmaceutical research, the determination of their ...
Zhanchao Li, Xuan Zhou, Zong Dai, Xiaoyong Zou
BMCBI
2010
113views more  BMCBI 2010»
14 years 10 months ago
Statistical method on nonrandom clustering with application to somatic mutations in cancer
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
Jingjing Ye, Adam Pavlícek, Elizabeth A. Lu...
BMCBI
2007
147views more  BMCBI 2007»
14 years 10 months ago
Improved residue contact prediction using support vector machines and a large feature set
Background: Predicting protein residue-residue contacts is an important 2D prediction task. It is useful for ab initio structure prediction and understanding protein folding. In s...
Jianlin Cheng, Pierre Baldi
BMCBI
2007
102views more  BMCBI 2007»
14 years 10 months ago
Identification of homologs in insignificant blast hits by exploiting extrinsic gene properties
Background: Homology is a key concept in both evolutionary biology and genomics. Detection of homology is crucial in fields like the functional annotation of protein sequences and...
Jos Boekhorst, Berend Snel