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BMCBI
2007
127views more  BMCBI 2007»
14 years 10 months ago
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines
Background: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The no...
Jian Tian, Ningfeng Wu, Xuexia Guo, Jun Guo, Juhua...
BIBE
2007
IEEE
167views Bioinformatics» more  BIBE 2007»
15 years 2 months ago
Assessing the Performance of Macromolecular Sequence Classifiers
Machine learning approaches offer some of the most cost-effective approaches to building predictive models (e.g., classifiers) in a broad range of applications in computational bio...
Cornelia Caragea, Jivko Sinapov, Vasant Honavar, D...
BMCBI
2008
102views more  BMCBI 2008»
14 years 10 months ago
Fast splice site detection using information content and feature reduction
Background: Accurate identification of splice sites in DNA sequences plays a key role in the prediction of gene structure in eukaryotes. Already many computational methods have be...
A. K. M. A. Baten, Saman K. Halgamuge, Bill C. H. ...
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BMCBI
2006
149views more  BMCBI 2006»
14 years 10 months ago
Curation of viral genomes: challenges, applications and the way forward
Background: Whole genome sequence data is a step towards generating the 'parts list' of life to understand the underlying principles of Biocomplexity. Genome sequencing ...
Urmila Kulkarni-Kale, Shriram Bhosle, G. Sunitha M...
BMCBI
2005
124views more  BMCBI 2005»
14 years 10 months ago
Evaluating concentration estimation errors in ELISA microarray experiments
Background: Enzyme-linked immunosorbent assay (ELISA) is a standard immunoassay to estimate a protein's concentration in a sample. Deploying ELISA in a microarray format perm...
Don Simone Daly, Amanda M. White, Susan M. Varnum,...