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BMCBI
2002
137views more  BMCBI 2002»
15 years 1 months ago
ORFer - retrieval of protein sequences and open reading frames from GenBank and storage into relational databases or text files
Background: Functional genomics involves the parallel experimentation with large sets of proteins. This requires management of large sets of open reading frames as a prerequisite ...
Konrad Büssow, Steve Hoffmann, Volker Sievert
BMCBI
2011
14 years 8 months ago
Flexible taxonomic assignment of ambiguous sequencing reads
Background: To characterize the diversity of bacterial populations in metagenomic studies, sequencing reads need to be accurately assigned to taxonomic units in a given reference ...
José Carlos Clemente, Jesper Jansson, Gabri...
138
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BMCBI
2010
153views more  BMCBI 2010»
15 years 1 months ago
Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massi
Background: Massively parallel sequencing readouts of epigenomic assays are enabling integrative genome-wide analyses of genomic and epigenomic variation. Pash 3.0 performs sequen...
Cristian Coarfa, Fuli Yu, Christopher A. Miller, Z...
111
Voted
BMCBI
2010
101views more  BMCBI 2010»
15 years 1 months ago
Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model
Background: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variat...
Zhengdong D. Zhang, Mark B. Gerstein
BMCBI
2011
14 years 5 months ago
Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence
Background: Alternative splicing of pre-mature RNA is an important process eukaryotes utilize to increase their repertoire of different protein products. Several types of differen...
Holger Pillmann, Klas Hatje, Florian Odronitz, Bjo...