2048 search results - page 391 / 410 » The Tale of Two Projects - Abstract |
143
click to vote
BMCBI
2010
15 years 3 months ago
2010
Background: Assembling genomic sequences from a set of overlapping reads is one of the most fundamental problems in computational biology. Algorithms addressing the assembly probl...
122
click to vote
BMCBI
2010
15 years 3 months ago
2010
Background: Finishing is the process of improving the quality and utility of draft genome sequences generated by shotgun sequencing and computational assembly. Finishing can invol...
122
click to vote
BMCBI
2008
15 years 3 months ago
2008
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
104
click to vote
BMCBI
2007
15 years 3 months ago
2007
Background: Whole genome shotgun sequencing produces increasingly higher coverage of a genome with random sequence reads. Progressive whole genome assembly and eventual finishing ...
141
click to vote
BMCBI
2008
15 years 3 months ago
2008
Background: With the completion of the Human Genome Project and recent advancements in mutation detection technologies, the volume of data available on genetic variations has rise...