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» The effect of sequence quality on sequence alignment
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117
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ISMB
2001
15 years 4 months ago
Using mixtures of common ancestors for estimating the probabilities of discrete events in biological sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Noble Grundy, Yoram Singer
153
Voted
JCB
2002
74views more  JCB 2002»
15 years 3 months ago
Using Substitution Matrices to Estimate Probability Distributions for Biological Sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Stafford Noble, Yoram Singe...
BMCBI
2008
109views more  BMCBI 2008»
15 years 3 months ago
ConStruct: Improved construction of RNA consensus structures
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
143
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BMCBI
2005
162views more  BMCBI 2005»
15 years 3 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes
BMCBI
2010
155views more  BMCBI 2010»
15 years 25 days ago
BrEPS: a flexible and automatic protocol to compute enzyme-specific sequence profiles for functional annotation
Background: Models for the simulation of metabolic networks require the accurate prediction of enzyme function. Based on a genomic sequence, enzymatic functions of gene products a...
Constantin Bannert, A. Welfle, C. aus dem Spring, ...