Background: With the exponential increase in genomic sequence data there is a need to develop automated approaches to deducing the biological functions of novel sequences with hig...
Background: Detection of common evolutionary origin (homology) is a primary means of inferring protein structure and function. At present, comparison of protein families represent...
Background: Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio...
Gianluca Pollastri, Alberto J. M. Martin, Catherin...
The Hierarchical Hidden Markov Model (HHMM) is a well formalized tool suitable to model complex patterns in long temporal or spatial sequences. Even if effective algorithms are ava...
Many applications in Comparative Genomics lend themselves to implementations that take advantage of common high-performance features in modern microprocessors. However, the common...
Christopher Mueller, Mehmet M. Dalkilic, Andrew Lu...