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BMCBI
2007
144views more  BMCBI 2007»
14 years 9 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...
90
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BMCBI
2010
108views more  BMCBI 2010»
14 years 9 months ago
An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs
Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs ...
Fernando Garcia-Alcalde, Armando Blanco, Adrian J....
BMCBI
2007
100views more  BMCBI 2007»
14 years 9 months ago
Discovering structural motifs using a structural alphabet: Application to magnesium-binding sites
Background: For many metalloproteins, sequence motifs characteristic of metal-binding sites have not been found or are so short that they would not be expected to be metal-specifi...
Minko Dudev, Carmay Lim
NAR
2007
130views more  NAR 2007»
14 years 9 months ago
The SLiMDisc server: short, linear motif discovery in proteins
Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein–protein interactions. Overrepresentation of convergent occurrences of mot...
Norman E. Davey, Richard J. Edwards, Denis C. Shie...
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
15 years 1 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee