41 search results - page 6 / 9 » The functional importance of disease-associated mutation |
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BMCBI
2007
14 years 9 months ago
2007
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
BMCBI
2002
14 years 9 months ago
2002
Background: When analyzing protein sequences using sequence similarity searches, orthologous sequences (that diverged by speciation) are more reliable predictors of a new protein&...
BMCBI
2008
2008
WSPMaker: a web tool for calculating selection pressure in proteins and domains using window-sliding
14 years 9 months ago
Background: In the study of adaptive evolution, it is important to detect the protein coding sites where natural selection is acting. In general, the ratio of the rate of non-syno...
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BMCBI
2008
14 years 9 months ago
2008
Background: Gene family identification from ESTs can be a valuable resource for analysis of genome evolution but presents unique challenges in organisms for which the entire genom...
BMCBI
2008
14 years 9 months ago
2008
Background: Modern proteomes evolved by modification of pre-existing ones. It is extremely important to comparative biology that related proteins be identified as members of the s...