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BMCBI
2010
105views more  BMCBI 2010»
14 years 12 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
123views more  BMCBI 2010»
14 years 12 months ago
A new protein binding pocket similarity measure based on comparison of clouds of atoms in 3D: application to ligand prediction
Background: Predicting which molecules can bind to a given binding site of a protein with known 3D structure is important to decipher the protein function, and useful in drug desi...
Brice Hoffmann, Mikhail Zaslavskiy, Jean-Philippe ...

Publication
141views
13 years 10 months ago
Measures of Diversity for Populations and Distances Between Individuals with Highly Reorganizable Genomes
In this paper we address the problem of defining a measure of diversity for a population of individuals whose genome can be subjected to major reorganizations during the evolution...
Claudio Mattiussi, Markus Waibel, Dario Floreano
MM
2009
ACM
177views Multimedia» more  MM 2009»
15 years 6 months ago
Transfer non-metric measures into metric for similarity search
Similarity search is widely used in multimedia retrieval systems to find the most similar ones for a given object. Some similarity measures, however, are not metric, leading to e...
Danzhou Liu, Kien A. Hua
DAGSTUHL
1994
15 years 1 months ago
Function-Based Object Recognition
Functionality-based recognition systems recognize objects at the category level by reasoning about how well the objects support the expected function. Such systems naturally assoc...
Louise Stark, Kevin W. Bowyer