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BMCBI
2008
14 years 9 months ago
2008
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
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DSS
2008
14 years 9 months ago
2008
As the Web continues to grow, it has become increasingly difficult to search for relevant information using traditional search engines. Topic-specific search engines provide an al...
BMCBI
2006
14 years 9 months ago
2006
Background: Local structures of target mRNAs play a significant role in determining the efficacies of antisense oligonucleotides (ODNs), but some structure-based target site selec...
BMCBI
2006
14 years 9 months ago
2006
Background: The structure of proteins may change as a result of the inherent flexibility of some protein regions. We develop and explore probabilistic machine learning methods for...
BMCBI
2006
14 years 9 months ago
2006
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...