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BMCBI
2011
14 years 1 months ago
A Beta-Mixture Model for Dimensionality Reduction, Sample Classification and Analysis
Background: Patterns of genome-wide methylation vary between tissue types. For example, cancer tissue shows markedly different patterns from those of normal tissue. In this paper ...
Kirsti Laurila, Bodil Oster, Claus L. Andersen, Ph...
BMCBI
2011
14 years 1 months ago
Binding Site Prediction for Protein-Protein Interactions and Novel Motif Discovery using Re-occurring Polypeptide Sequences
Background: While there are many methods for predicting protein-protein interaction, very few can determine the specific site of interaction on each protein. Characterization of t...
Adam Amos-Binks, Catalin Patulea, Sylvain Pitre, A...
BMCBI
2011
14 years 1 months ago
Software comparison for evaluating genomic copy number variation for Affymetrix 6.0 SNP array platform
Background: Copy number data are routinely being extracted from genome-wide association study chips using a variety of software. We empirically evaluated and compared four freely-...
Jeanette E. Eckel-Passow, Elizabeth J. Atkinson, S...
BMCBI
2011
14 years 1 months ago
HomPPI: A Class of Sequence Homology Based Protein-Protein Interface Prediction Methods
Background: Although homology-based methods are among the most widely used methods for predicting the structure and function of proteins, the question as to whether interface sequ...
Li C. Xue, Drena Dobbs, Vasant Honavar
BMCBI
2011
14 years 1 months ago
AMDORAP: Non-targeted metabolic profiling based on high-resolution LC-MS
Background: Liquid chromatography-mass spectrometry (LC-MS) utilizing the high-resolution power of an orbitrap is an important analytical technique for both metabolomics and prote...
Hiroki Takahashi, Takuya Morimoto, Naotake Ogasawa...
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