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131
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BMCBI
2007
113views more  BMCBI 2007»
15 years 1 months ago
Statistical power of phylo-HMM for evolutionarily conserved element detection
Background: An important goal of comparative genomics is the identification of functional elements through conservation analysis. Phylo-HMM was recently introduced to detect conse...
Xiaodan Fan, Jun Zhu, Eric E. Schadt, Jun S. Liu
123
Voted
BMCBI
2007
128views more  BMCBI 2007»
15 years 1 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
122
Voted
SAC
2006
ACM
15 years 1 months ago
Combining supervised and unsupervised monitoring for fault detection in distributed computing systems
Fast and accurate fault detection is becoming an essential component of management software for mission critical systems. A good fault detector makes possible to initiate repair a...
Haifeng Chen, Guofei Jiang, Cristian Ungureanu, Ke...
BMCBI
2005
132views more  BMCBI 2005»
15 years 1 months ago
Kalign - an accurate and fast multiple sequence alignment algorithm
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
Timo Lassmann, Erik L. L. Sonnhammer
106
Voted
BMCBI
2005
169views more  BMCBI 2005»
15 years 1 months ago
An adaptive method for cDNA microarray normalization
Background: Normalization is a critical step in analysis of gene expression profiles. For duallabeled arrays, global normalization assumes that the majority of the genes on the ar...
Yingdong Zhao, Ming-Chung Li, Richard Simon