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» Two Methods for Improving Performance of a HMM and their App...
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BMCBI
2006
86views more  BMCBI 2006»
13 years 6 months ago
MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution
Background: Non-coding DNA sequences comprise a very large proportion of the total genomic content of mammals, most other vertebrates, many invertebrates, and most plants. Unravel...
Jun Wang, Peter D. Keightley, Toby Johnson
BMCBI
2007
142views more  BMCBI 2007»
13 years 6 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2007
164views more  BMCBI 2007»
13 years 6 months ago
SEARCHPATTOOL: a new method for mining the most specific frequent patterns for binding sites with application to prokaryotic DNA
Background: Computational methods to predict transcription factor binding sites (TFBS) based on exhaustive algorithms are guaranteed to find the best patterns but are often limite...
Fathi Elloumi, Martha Nason
BMCBI
2010
104views more  BMCBI 2010»
13 years 1 months ago
A systematic study of genome context methods: calibration, normalization and combination
Background: Genome context methods have been introduced in the last decade as automatic methods to predict functional relatedness between genes in a target genome using the patter...
Luciana Ferrer, Joseph M. Dale, Peter D. Karp
BMCBI
2008
128views more  BMCBI 2008»
13 years 6 months ago
Improving the prediction accuracy in classification using the combined data sets by ranks of gene expressions
Background: The information from different data sets experimented under different conditions may be inconsistent even though they are performed with the same research objectives. ...
Ki-Yeol Kim, Dong Hyuk Ki, Hei-Cheul Jeung, Hyun C...