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BMCBI
2010
130views more  BMCBI 2010»
15 years 4 months ago
A statistical approach to finding overlooked genetic associations
Background: Complexity and noise in expression quantitative trait loci (eQTL) studies make it difficult to distinguish potential regulatory relationships among the many interactio...
Andrew K. Rider, Geoffrey Siwo, Nitesh V. Chawla, ...
BMCBI
2007
105views more  BMCBI 2007»
15 years 4 months ago
Generating confidence intervals on biological networks
Background: In the analysis of networks we frequently require the statistical significance of some network statistic, such as measures of similarity for the properties of interact...
Thomas Thorne, Michael P. H. Stumpf
BMCBI
2008
122views more  BMCBI 2008»
15 years 4 months ago
Reconstructing networks of pathways via significance analysis of their intersections
Background: Significance analysis at single gene level may suffer from the limited number of samples and experimental noise that can severely limit the power of the chosen statist...
Mirko Francesconi, Daniel Remondini, Nicola Nerett...
BMCBI
2006
116views more  BMCBI 2006»
15 years 4 months ago
Gene annotation and network inference by phylogenetic profiling
Background: Phylogenetic analysis is emerging as one of the most informative computational methods for the annotation of genes and identification of evolutionary modules of functi...
Jie Wu, Zhenjun Hu, Charles DeLisi
BMCBI
2005
112views more  BMCBI 2005»
15 years 4 months ago
Towards precise classification of cancers based on robust gene functional expression profiles
Background: Development of robust and efficient methods for analyzing and interpreting high dimension gene expression profiles continues to be a focus in computational biology. Th...
Zheng Guo, Tianwen Zhang, Xia Li, Qi Wang, Jianzhe...