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113
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IJON
2006
112views more  IJON 2006»
15 years 11 days ago
Comparison of automated parameter estimation methods for neuronal signaling networks
This work is a suitability study of the different optimization methods for automated parameter estimation (fitting) in the context of neuronal signaling networks. The Gepasi simul...
Antti Pettinen, Olli Yli-Harja, Marja-Leena Linne
BIOSYSTEMS
2007
175views more  BIOSYSTEMS 2007»
15 years 15 days ago
Alternative routes and mutational robustness in complex regulatory networks
Alternative pathways through a gene regulation network connect a regulatory molecule to its (indirect) regulatory target via different intermediate regulators. We here show for tw...
Andreas Wagner, Jeremiah Wright
129
Voted
RECOMB
2006
Springer
16 years 21 days ago
De Novo Signaling Pathway Predictions Based on Protein-Protein Interaction, Targeted Therapy and Protein Microarray Analysis
Abstract. Mapping intra-cellular signaling networks is a critical step in developing an understanding of and treatments for many devastating diseases. The predominant ways of disco...
Derek A. Ruths, Jen-Te Tseng, Luay Nakhleh, Prahla...
BMCBI
2006
133views more  BMCBI 2006»
15 years 13 days ago
Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae
Background: Signal recognition and information processing is a fundamental cellular function, which in part involves comprehensive transcriptional regulatory (TR) mechanisms carri...
Illés J. Farkas, Chuang Wu, Chakra Chennubh...
103
Voted
BMCBI
2008
133views more  BMCBI 2008»
15 years 15 days ago
SPIKE - a database, visualization and analysis tool of cellular signaling pathways
Background: Biological signaling pathways that govern cellular physiology form an intricate web of tightly regulated interlocking processes. Data on these regulatory networks are ...
Ran Elkon, Rita Vesterman, Nira Amit, Igor Ulitsky...