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BIBE
2006
IEEE
119views Bioinformatics» more  BIBE 2006»
15 years 4 months ago
Large Grain Size Stochastic Optimization Alignment
DNA sequence alignment is a critical step in identifying homology between organisms. The most widely used alignment program, ClustalW, is known to suffer from the local minima pro...
Perry Ridge, Hyrum Carroll, Dan Sneddon, Mark J. C...
ATAL
2005
Springer
15 years 3 months ago
Improving reinforcement learning function approximators via neuroevolution
Reinforcement learning problems are commonly tackled with temporal difference methods, which use dynamic programming and statistical sampling to estimate the long-term value of ta...
Shimon Whiteson
BMCBI
2008
106views more  BMCBI 2008»
14 years 10 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
ISPD
2010
ACM
217views Hardware» more  ISPD 2010»
15 years 5 months ago
ITOP: integrating timing optimization within placement
Timing-driven placement is a critical step in nanometerscale physical synthesis. To improve design timing on a global scale, net-weight based global timing-driven placement is a c...
Natarajan Viswanathan, Gi-Joon Nam, Jarrod A. Roy,...
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BMCBI
2007
171views more  BMCBI 2007»
14 years 10 months ago
An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed,
Background: Identifying relevant research in an ever-growing body of published literature is becoming increasingly difficult. Establishing domain-specific knowledge bases may be a...
Wei Yu, Ajay Yesupriya, Anja Wulf, Junfeng Qu, Mui...