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148
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BMCBI
2010
15 years 4 months ago
2010
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
123
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BMCBI
2007
15 years 4 months ago
2007
Background: Since real time PCR was first developed, several approaches to estimating the initial quantity of template in an RT-PCR reaction have been tried. While initially only ...
139
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BMCBI
2008
15 years 4 months ago
2008
Background: A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy. High-throughput screening (HTS) in drug di...
129
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BMCBI
2007
15 years 4 months ago
2007
Background: The advent of RNA interference techniques enables the selective silencing of biologically interesting genes in an efficient way. In combination with DNA microarray tec...
160
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BMCBI
2008
15 years 4 months ago
2008
Background: Biological chemistry is very stereospecific. Nonetheless, the diastereotopic oxygen atoms of diphosphate-containing molecules in the Protein Data Bank (PDB) are often ...