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» Using an Agile Approach in a Large, Traditional Organization
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AIEDAM
2007
105views more  AIEDAM 2007»
14 years 12 months ago
Biomimetic design through natural language analysis to facilitate cross-domain information retrieval
Biomimetic, or biologically inspired, design uses analogous biological phenomena to develop solutions for engineering problems. Several instances of biomimetic design result from ...
Ivey Chiu, L. H. Shu
BMCBI
2008
161views more  BMCBI 2008»
14 years 12 months ago
Inferring gene expression dynamics via functional regression analysis
Background: Temporal gene expression profiles characterize the time-dynamics of expression of specific genes and are increasingly collected in current gene expression experiments....
Hans-Georg Müller, Jeng-Min Chiou, Xiaoyan Le...
BMCBI
2007
207views more  BMCBI 2007»
14 years 12 months ago
Analyzing in situ gene expression in the mouse brain with image registration, feature extraction and block clustering
Background: Many important high throughput projects use in situ hybridization and may require the analysis of images of spatial cross sections of organisms taken with cellular lev...
Manjunatha Jagalur, Chris Pal, Erik G. Learned-Mil...
BMCBI
2010
137views more  BMCBI 2010»
14 years 12 months ago
BS Seeker: precise mapping for bisulfite sequencing
Background: Bisulfite sequencing using next generation sequencers yields genome-wide measurements of DNA methylation at single nucleotide resolution. Traditional aligners are not ...
Pao-Yang Chen, Shawn Cokus, Matteo Pellegrini
BMCBI
2007
99views more  BMCBI 2007»
14 years 12 months ago
Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Ki
Background: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure ...
Jenny Gu, Philip E. Bourne