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BMCBI
2008
118views more  BMCBI 2008»
14 years 11 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden
BMCBI
2007
162views more  BMCBI 2007»
14 years 11 months ago
Three-Dimensional Phylogeny Explorer: Distinguishing paralogs, lateral transfer, and violation of "molecular clock" assumption w
Background: Construction and interpretation of phylogenetic trees has been a major research topic for understanding the evolution of genes. Increases in sequence data and complexi...
Namshin Kim, Christopher Lee
BIOINFORMATICS
2005
152views more  BIOINFORMATICS 2005»
14 years 11 months ago
Intervention in context-sensitive probabilistic Boolean networks
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
Ranadip Pal, Aniruddha Datta, Michael L. Bittner, ...
GECCO
1999
Springer
130views Optimization» more  GECCO 1999»
15 years 3 months ago
Heterochrony and Adaptation in Developing Neural Networks
This paper discusses the simulation results of a model of biological development for neural networks based on a regulatory genome. The model’s results are analyzed using the fra...
Angelo Cangelosi
RECOMB
2004
Springer
15 years 12 months ago
Computational identification of evolutionarily conserved exons
Phylogenetic hidden Markov models (phylo-HMMs) have recently been proposed as a means for addressing a multispecies version of the ab initio gene prediction problem. These models ...
Adam C. Siepel, David Haussler