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BMCBI
2007
126views more  BMCBI 2007»
14 years 11 months ago
Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation
Background: Biochemical investigations over the last decades have elucidated an increasingly complete image of the cellular metabolism. To derive a systems view for the regulation...
Gunnar Schramm, Marc Zapatka, Roland Eils, Rainer ...
BMCBI
2007
102views more  BMCBI 2007»
14 years 11 months ago
Setting up a large set of protein-ligand PDB complexes for the development and validation of knowledge-based docking algorithms
Background: The number of algorithms available to predict ligand-protein interactions is large and ever-increasing. The number of test cases used to validate these methods is usua...
Luis A. Diago, Persy Morell, Longendri Aguilera, E...
BMCBI
2007
124views more  BMCBI 2007»
14 years 11 months ago
Protein structural similarity search by Ramachandran codes
Background: Protein structural data has increased exponentially, such that fast and accurate tools are necessary to access structure similarity search. To improve the search speed...
Wei-Cheng Lo, Po-Jung Huang, Chih-Hung Chang, Ping...
BMCBI
2007
107views more  BMCBI 2007»
14 years 11 months ago
A computational approach for detecting peptidases and their specific inhibitors at the genome level
Background: Peptidases are proteolytic enzymes responsible for fundamental cellular activities in all organisms. Apparently about 2–5% of the genes encode for peptidases, irresp...
Lisa Bartoli, Remo Calabrese, Piero Fariselli, Dam...
FSS
2006
140views more  FSS 2006»
14 years 11 months ago
Advances and challenges in interval-valued fuzzy logic
Among the various extensions to the common [0, 1]-valued truth degrees of "traditional" fuzzy set theory, closed intervals of [0, 1] stand out as a particularly appealin...
Chris Cornelis, Glad Deschrijver, Etienne E. Kerre