Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
Background: Owing to the rapid expansion of RNA structure databases in recent years, efficient methods for structure comparison are in demand for function prediction and evolution...
Background: It has been suggested previously that genome and proteome sequences show characteristics typical of natural-language texts such as “signature-style” word usage ind...
We present a simple statistical model of molecular function evolution to predict protein function. The model description encodes general knowledge of how molecular function evolve...
Barbara E. Engelhardt, Michael I. Jordan, Steven E...
We describe an approach for pipelining nested data collections in scientific workflows. Our approach logically delimits arbitrarily nested collections of data tokens using special...