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BMCBI
2007
146views more  BMCBI 2007»
14 years 11 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
BMCBI
2005
201views more  BMCBI 2005»
14 years 11 months ago
Principal component analysis for predicting transcription-factor binding motifs from array-derived data
Background: The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to...
Yunlong Liu, Matthew P. Vincenti, Hiroki Yokota
107
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TIT
2010
118views Education» more  TIT 2010»
14 years 6 months ago
Joint sampling distribution between actual and estimated classification errors for linear discriminant analysis
Error estimation must be used to find the accuracy of a designed classifier, an issue that is critical in biomarker discovery for disease diagnosis and prognosis in genomics and p...
Amin Zollanvari, Ulisses Braga-Neto, Edward R. Dou...
86
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BMCBI
2010
95views more  BMCBI 2010»
14 years 11 months ago
An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data
Background: ChIP-Seq, which combines chromatin immunoprecipitation (ChIP) with high-throughput massively parallel sequencing, is increasingly being used for identification of prot...
Congmao Wang, Jie Xu, Dasheng Zhang, Zoe A. Wilson...
BMCBI
2010
155views more  BMCBI 2010»
14 years 11 months ago
A bi-ordering approach to linking gene expression with clinical annotations in gastric cancer
Background: In the study of cancer genomics, gene expression microarrays, which measure thousands of genes in a single assay, provide abundant information for the investigation of...
Fan Shi, Christopher Leckie, Geoff MacIntyre, Izha...