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IMCS
2007
144views more  IMCS 2007»
14 years 11 months ago
On the imbalance of the security problem space and its expected consequences
Purpose – This paper aims to report on the results of an analysis of the computer security problem space, to suggest the areas with highest potential for making progress in the ...
Konstantin Beznosov, Olga Beznosova
BMCBI
2005
133views more  BMCBI 2005»
14 years 11 months ago
Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops
Background: Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to add...
Hélène Chiapello, I. Bourgait, F. So...
BMCBI
2005
123views more  BMCBI 2005»
14 years 11 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas
BMCBI
2005
94views more  BMCBI 2005»
14 years 11 months ago
Computational identification of strain-, species- and genus-specific proteins
Background: The identification of unique proteins at different taxonomic levels has both scientific and practical value. Strain-, species- and genus-specific proteins can provide ...
Raja Mazumder, Darren A. Natale, Sudhir Murthy, Ra...
BMCBI
2005
152views more  BMCBI 2005»
14 years 11 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer